(Dr. Steven Chan Lab)
Job no: H03/2023/C1/UHN
Location: Hong Kong Science Park
Role type: Full time
Centre for Oncology and Immunology Limited
The long-term objective of the Centre for Oncology and Immunology is to employ novel functional screens, animal and cell models including organoids, immune-oncology approach, as well as advanced genomic and proteomic techniques down to single cell resolution to identify novel “druggable” cancer targets for hard-to-treat malignancies. The ultimate goal is to develop therapeutics against these targets and to conduct clinical trials evaluating these drugs along with biomarkers with an eye to their eventual commercialization worldwide. Success in this venture will address pressing unmet medical needs and establish Hong Kong as a leading hub of innovative anti-cancer and immuno-oncology drug development.
The position will focus on acute myeloid leukemia under the direction of Dr. Steven Chan as part of a collaborative program between the University of Hong Kong and the University Health Network/Princess Margaret Cancer Centre (Canada). The successful candidate will work in close collaboration with the principal investigator’s scientific teams at the Centre for Oncology and Immunology and the Princess Margaret Cancer Centre to systemically decipher the synthetic lethal interactions with mutations that are commonly found in myeloid malignancies (e.g, acute myeloid leukemia) using state-of-art functional genomics tools.
Candidates are expected to perform collaborative research projects in the discovery of synthetic lethal interactions using large scale functional genomics approaches and novel animal models. Candidates will also be involved in the development of novel compounds against established targets.
Qualifications and skills:
Applicants with strong research background in Molecular Biology is required. A strong background in other fields of biomedical sciences including Cancer Biology, Genomics, Metabolomics, Bioinformatics, Single Cell Technology or Medicinal Chemistry is highly desirable.
Possess a demonstrated track record of publishing academic research papers
Understanding and/or experience in CRISPR/Cas9 technology, high-throughput screening techniques, next generation sequencing, and single cell sequencing technologies
Experienced in molecular biology laboratory techniques (including cloning) and handling mammalian cell culture
Specialised research interest in multi-omics profiling, bioinformatics, cancer metabolism, medicinal chemistry, and drug discovery
Experienced in mouse models, xenograft models and biobanking
Experienced in animal handling technique
Applicants should have a good command of written and spoken English, strong communication skills, and be self-motivated, hardworking and able to work well in an interdisciplinary team.
The appointees shall work in Hong Kong Science and Technology Park.
Overseas graduate is welcome to apply, the qualification awarding institution should be the top 100 institutions for STEM-related subjects in QS/Shanghai Jiao Tong Uni/Times Higher Education/U.S. News world university rankings.
Applicants for the Postdoctoral Fellow posts should possess a Ph.D. degree or an equivalent qualification in one of the said or related disciplines. (H03/2023/C1/UHN)
A highly competitive salary commensurate with qualifications and experience will be offered, in addition to annual leave and medical benefits.
How to apply:
Applicants should submit their up-to-date C.V. and research publication list, quoting the job reference number, with information of current/expected remuneration and availability, to firstname.lastname@example.org or by clicking "Apply".
Review of applications will commence as soon as possible or until the posts are filled, whichever is earlier.
The personal data provided in your application process will be used for recruitment and other employment-related purposes. The personal data may be transferred and disclosed to, and used by HKU Innovation Holdings Limited and The University of Hong Kong for the above purposes.
We are an equal opportunities employer and welcome applications from all qualified candidates.